Author + information
- Sabina A. Murphy, MPH∗ (, )
- Christopher P. Cannon, MD,
- Michael A. Blazing, MD,
- Robert P. Giugliano, MD,
- Andrew M. Tershakovec, MD, MPH and
- Eugene Braunwald, MD
- ↵∗TIMI Study Group, 350 Longwood Ave, 1st Floor, Boston, Massachusetts 02115
We thank Dr. Weingärtner and colleagues for their interest in our paper (1) and we appreciate the suggestion to test the strategy of evaluating the ratio of cholesterol absorption and synthesis. Analyses of cholesterol production and cholesterol absorption are currently under way in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial). It will be of interest to evaluate the association with both first and total cardiovascular events, particularly in relation to nonfatal myocardial infarctions and nonfatal ischemic strokes, given the underlying pathophysiological mechanism of atherosclerotic plaque rupture.
Please note: Ms. Murphy has received modest personal fees from Merck & Co. and Amarin. Dr Cannon has received grant support from Accumentrics, Arisaph, and Janssen; grant support and personal fees from Takeda; and personal fees from Bristol-Myers Squibb, CSL Behring, Essentialis, Kowa, Lipimedix, Pfizer, Regeneron, Boehringer Ingelheim, GlaxoSmithKline, Merck & Co., Inc., and Sanofi. Dr Blazing has received grant support from Merck during the conduct of the study; and personal fees from Merck, Sanofi, Amgen, Novartis, AstraZeneca, and Pfizer. Dr Giugliano has received grant support from Merck during the conduct of the study; grant support and personal fees from Amgen; and personal fees from Merck, Daiichi-Sankyo, Pfizer, CVS Caremark, Regeneron, and Sanofi. Dr. Tershakovec is an employee of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co, Inc., and may hold stock/stock options in the company. Dr. Braunwald has received grant support from Merck during the conduct of the study and personal fees from Daiichi-Sankyo, Sanofi, The Medicines Company, Menarini International, Bayer, and Medscape.
- American College of Cardiology Foundation