Author + information
- Peter Libby, MD∗ (, )
- Matthias Nahrendorf, MD and
- Filip K. Swirski, PhD
- ↵∗Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115
We thank Dr. Chen and colleagues for their interest in our recent paper (1). We agree completely with the importance of the sympathetic nervous system as a modulator of leukocyte functions and hematopoiesis. Indeed, similar to the diagram that they provide, the central Figure of our publication depicts explicitly the links between the central nervous system, sympathetic outflow, and beta3-adrenergic signaling as a stimulator of overproduction of leukocytes under stress conditions such as acute myocardial infarction. We described this pathway in the paper by Dutta et al. (2) cited in their letter. We thank these readers for their appreciation of this important point.
Please note: Dr. Libby is involved in consulting in clinical trials; receives sponsored research support from Novartis; and receives funding from the National Heart, Lung, and Blood Institute (R01 HL080472). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- American College of Cardiology Foundation