Author + information
- Vasvi Singh,
- Vijay Iyer,
- Asma Mursleen,
- Rosemary Hansen,
- Stanley Fernandez and
- Saurabh Malhotra
Background: Myocardial contractility, measured as LV global longitudinal strain (LV-GLS), predicts clinical outcomes. Transcatheter Aortic Valve Replacement (TAVR), a treatment of severe aortic stenosis in high-risk patients, results in afterload reduction and change in myocardial contractility. We aimed to determine the temporality of the change in myocardial contractility after TAVR and its relationship with quality of life.
Methods: LV-GLS was assessed from transthoracic echocardiograms (n=41), obtained intraoperatively pre-TAVR, intraoperatively immediately after valve deployment, 1-day and 1-month after TAVR. Kansas City Cardiomyopathy Questionnaire (KCCQ) was used to measure quality of life and was administered both prior to and after TAVR.
Results: The mean age of the population was 82+7 years (49% males). The mean KCCQ score prior to and after TAVR were (34+8 vs. 57+9, p<0.0001). There was a sequential improvement in LV-GLS at each time point when compared to intraoperative pre-TAVR strain, though the change being statistically different only at 1-day and 1-month after TAVR (figure). There was no difference in LV-GLS at 1-day and 1-month after TAVR (p=0.12). LV-GLS at each time point after TAVR significantly correlated with improvement in KCCQ score (table).
Conclusions: There is an immediate improvement in myocardial contractility after TAVR that continues to improve over time. Improvement in myocardial contractility after TAVR correlates with improvement in quality of life.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Interventional Cardiology: TAVR 1
Abstract Category: 17. Interventional Cardiology: Aortic Valve Disease
Presentation Number: 1114-162
- 2017 American College of Cardiology Foundation