Author + information
- Samir B. Pancholy,
- Sukrut Nanavaty,
- Neha Pancholy,
- Maitri Pancholy,
- Kavit Pandya,
- John Coppola,
- Tak Kwan,
- Tejas Patel,
- Aman Patel and
- Hemant Tiwari
Background: Fractional flow reserve (FFR) measured using coronary vasodilation has become standard of care for evaluation of hemodynamic lesion significance. Instantaneous wave free ratio (IFR) is becoming popular due to the lack of the necessity to induce vasodilatation.
Patients and Methods: 33 patients undergoing diagnostic coronary angiography were prospectively enrolled in the study. Baseline Pd/Pa and IFR were recorded. Intracoronary bolus injection of 10 ml of radiocontrast material with rapid flushing with normal saline was performed and post-contrast IFR (CIFR) was recorded. 140 mcg/kg/minute of intravenous Adenosine infusion was given for 4 minutes and FFR as well as IFR was recorded. Bland-Altman Plot was generated to compare CIFR to Adenosine FFR (AFFR).
Results: CIFR was found to be comparable to AFFR, with Bland-Altman bias = 0.01 (Figure 1). Dichotomizing AFFR at 0.8 and CIFR at 0.8, c-statistic was 0.87, indicating comparable discriminatory power of CIFR to that of AFFR in determining hemodynamic significance of coronary stenosis for interventional decision making (Figure 1).
Conclusions: CIFR could be used to determine lesion significance, maintaining the same level of accuracy as AFFR, and eliminating the need for adenosine, improving cost and side effects.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Interventional Cardiology: Intravascular Physiology and Endothelial Function
Abstract Category: 23. Interventional Cardiology: IVUS and Intravascular Physiology
Presentation Number: 1115-179
- 2017 American College of Cardiology Foundation