Author + information
- Erika Yamamoto,
- Takumi Higuma,
- Lei Xing,
- Yoshiyasu Minami,
- Krzysztof Bryniarski,
- Jiannan Dai,
- Thomas Zanchin,
- Tomoyo Sugiyama,
- Zhao Wang,
- Aaron Aguirre,
- Hang Lee and
- Ik-Kyung Jang
Background: The difference in neointimal pattern between first generation drug eluting stent (G1-DES) and second generation DES (G2-DES) and its clinical significance have not been systematically studied.
Methods: A total of 499 patients with 696 DES, who underwent follow-up optical coherence tomography (OCT) study were included. Qualitative and quantitative analysis of neointima were performed and the results were compared between the two groups at early (1–6 months) and late (6–36 months) follow up. Neointimal patterns were correlated with target lesion revascularization (TLR) at 3 years.
Result: The incidence of non-homogeneous (heterogeneous+layered+neoatherosclerosis) neointima tended to be higher in G2-DES than in G1-DES at early phase (10.5% vs 22.7%, p = 0.08) and tended to be lower in G2-DES at late phase (26.6% vs 19.3%, p = 0.07). Cumulative incidence of TLR was significantly higher in non-homogeneous neointima than in homogeneous neointima (6.0% vs 0.8%, p = 0.008). Statin use (OR: 0.40, 95% CI: 0.20 – 0.79, p = 0.008) and G2-DES (OR: 0.58, 95% CI: 0.36 – 0.95, p = 0.03) were the independent negative predictors for non-homogeneous neointima.
Conclusions: Compared to G1-DES, G2-DES has a trend toward higher incidence of non-homogeneous neointima in early phase and lower incidence of non-homogenous neointima in late phase. Non-homogeneous pattern is associated with a higher incidence of TLR. Statin and G2-DES have protective effects on development of non-homogeneous neointima.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Interventional Cardiology: Intravascular Physiology and Endothelial Function
Abstract Category: 23. Interventional Cardiology: IVUS and Intravascular Physiology
Presentation Number: 1115-184
- 2017 American College of Cardiology Foundation