Author + information
- Simon Winther,
- My Svensson,
- Hanne S. Jørgensen,
- Laust D. Rasmussen,
- Lars Gormsen,
- Niels Holm,
- Kirsten Bouchelouche,
- Hans Erik Boetker,
- Per Ivarsen and
- Morten Boettcher
Purpose: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates. Noninvasive stress imaging is preferred, despite low diagnostic accuracy and conflicting study results about the prognostic value. The aim of this study was to assess the predictive value of coronary CT angiography (CCTA), single-photon emission CT (SPECT), and invasive coronary angiography (ICA) for MACE and all-cause mortality.
Methods: We prospectively evaluated patients referred for kidney transplantation by CCTA, SPECT and ICA. An abnormal test result was defined as >50 % diameter stenosis by CCTA or ICA. SPECT was analyzed according to clinical guidelines. Clinical endpoints were extracted from patient interviews, patient records and the Western Denmark Heart Registry.
Results: We enrolled 154 patients, mean age 54 [range: 22–72] years, 67% males and 44% was treated with dialysis. Mean follow-up time was 3.7 [range: 0.3–5.7] years. In total, 27 (14.5%) patients had a MACE and 30 (19.5%) patients died. In time to event analysis, CCTA and ICA predicted MACE and only CCTA predicted mortality (figure).
Conclusions: In contrast to SPECT, ICA predicts MACE and CCTA predicts both MACE and mortality during long-term follow-up. CCTA seems recommendable for risk stratification of kidney transplant candidates.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: PCI for NSTEMI and Complex Patients With Multiple Co-Morbidities
Abstract Category: 19. Interventional Cardiology: Complex Patients/Comorbidities
Presentation Number: 1154-139
- 2017 American College of Cardiology Foundation