Author + information
- Todd J. Brinton,
- Ziad Ali,
- Carlo Di Mario,
- Jonathan Hill,
- Robert Whitbourn,
- Matthias Gotberg,
- Uday Illindala,
- Akiko Maehara,
- Nicolas Van Mieghem,
- Ian Meredith and
- Jean Fajadet
Background: Coronary artery calcification presents multiple challenges to percutaneous revascularization and is associated with suboptimal results and adverse long-term clinical outcomes. Lithoplasty treatment is a balloon-based therapy deploying circumferential lithotripsy to disrupt intimal and medial calcium prior to low pressure balloon expansion. This study evaluated the safety and performance of Coronary Lithoplasty to treat calcified, de novo coronary lesions prior to stenting.
Methods: Disrupt CAD is a prospective, multi-center, single-arm study in which patients (N=60) with moderate to severe calcification were treated with the Coronary Rx Lithoplasty System (Shockwave Medical, Inc, Fremont, CA) between December 2015 and September 2016. A total of 31 patients had optical coherence tomography (OCT) performed before and after treatment.
Results: OCT derived cross sectional areas and quantification of calcification are summarized in tertiles. (Table)
Conclusions: The DISRUPT CAD OCT sub-study demonstrated substantial acute gain and stent areas in a difficult to treat population. The technology was equally effective in the most difficult to treat patients based on degree of calcification. Lithoplasty treatment is an promising new balloon-based technology for calcified lesions.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Coronary Intervention in Interventional Cardiology: Advanced Device Use
Abstract Category: 21. Interventional Cardiology: Coronary Intervention: Devices
Presentation Number: 1155-162
- 2017 American College of Cardiology Foundation