Author + information
- Rocío González Ferreiro,
- Diego Lopez Otero,
- Antonio J. Muñoz-García,
- Pablo Avanzas,
- Isaac Pascual,
- Juan H. Alonso Briales,
- Ramiro Trillo Nouche,
- Federico Pun Chinchay,
- Manuel Jimenez Navarro,
- Jose Maria Hernandez Garcia,
- Cesar Moris and
- Jose Ramon Gonzalez Juanatey
Background: In the context of established cardiovascular disease, obesity is protective factor (obesity paradox). The aim of our study is to determine if the body mass index (BMI) is a prognostic factor in patients undergoing transcatheter aortic valve implantation (TAVI).
Methods: A retrospective study was carried out in three centers.770 patients undergoing TAVI between 2008-2014, were distributed according to their BMI in 3 groups: normal weight, overweight and obesity. The study endpoint was to assess the value of BMI to predict all-cause mortality during follow-up.
Results: A total of 155 patients died during follow-up (2,7±1,8 years). The overweight group (n=302,38,97%) has a lower mortality rate compared with normal weight and obese groups (15,9% vs 25,7% y 21,0%; log-rank p-value 0,036). After multivariate Cox regression analysis, overweight was independent protective factor for mortality (HR: 0.63 [95% CI: 0.42 to 0.94], p=0.024), not obesity (HR: 0.92 [95% CI: 0.63 to 1.35], p=0.664). In our study we describe for the first time a “J”-shaped regression, that relates the BMI with long-term mortality (figure 1). Thus, patients at the extremes of the curve (underweight and extreme obesity) has the worst prognosis, whereas patients who are overweight have the most favorable prognosis.
Conclusions: BMI has prognostic value in patients with severe aortic stenosis undergoing TAVI, with a “J”-shaped curve. Overweight was associated with lower long-term motality rate.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Interventional Cardiology: TAVR 2
Abstract Category: 17. Interventional Cardiology: Aortic Valve Disease
Presentation Number: 1195-191
- 2017 American College of Cardiology Foundation