Author + information
- Parasuram Krishnamoorthya,b,
- Mario Naranjoa,b,
- Nikoloz Koshkelashvilia,b,
- Akshaya Gopalakrishnana,b,
- Alexandra Tulucaa,b,
- Janani Rangaswamia,b,
- Vincent Figueredoa,b,
- Mark Andersona,b and
- Dennis Morrisa,b
Background: White blood cell (WBC) count is a marker of systemic inflammation and is associated with increased cardiovascular risk. Inflammation is also associated with increased platelet reactivity. Hence, we aimed to determine the usefulness of WBC to platelet count ratio (WPR) for predicting outcomes in patients requiring circulatory support with left ventricular impella assist devices.
Methods: We analyzed data from 100 consecutive patients referred to the Einstein Medical Center cardiac catheterization laboratory from 2012 to 2015 undergoing left ventricular percutaneous impella assist device placement. Demographic data, traditional cardiovascular risk factors, procedure indication, baseline LV ejection fraction, baseline hematology indices and renal function were collected. Primary outcome of interest was in-hospital death. Logistic regression analysis was performed to determine predictors of in-hospital death.
Results: Mean age of the population was 66.8±14 years and more commonly males (68%), with 85.2% having acute coronary syndrome and 78.2% in cardiogenic shock at presentation. In hospital mortality was 37.6%. WPR predicted increased in-hospital death [OR 1.37 (1.13-1.65); p<0.001)] in unadjusted model. When adjusted for demographic and risk factors, presence of ST segment elevation MI, baseline LVEF and renal function, WPR was still associated with increased in-hospital death [OR 1.57 (1.03-2.22; p=0.03)].
Conclusions: Increased WPR was associated with increased in-hospital death in patients requiring circulatory support with left ventricular impella assist device. Hence, WPR may be used to risk stratify and direct aggressive therapies to reduce mortality in patients with elevated WPR. Additional studies are needed to determine the mechanism(s) for this association.
Poster Contributions Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Coronary Intervention: Drug Eluting Stent & Scaffolds
Abstract Category: 21. Interventional Cardiology: Coronary Intervention: Devices
Presentation Number: 1240-134
- 2017 American College of Cardiology Foundation