Author + information
- Roberto Spina,
- David Muller and
- Brendan Gunalingam
Background: Atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) are produced by mammalian cardiomyocytes located in the atria and atrial appendages. These hormones are released in response to chamber distension, and have potent natriuretic, diuretic, and vasodilator activity. Surgical removal of the atrial appendages results in diminished ANP release and blunted renal excretion of sodium and water in response to volume expansion compared to control subjects. We investigated the effects of transcatheter left atrial appendage occlusion (T-LAAO) on the secretion of atrial natriuretic peptides, natriuresis and diuresis.
Methods: The study was a single-centre prospective non-randomized study of T-LAAO with the Watchman device (Boston Scientific, USA) versus control (no intervention) in patients with non-valvular AF and a CHA2DS2VASc score ≥ 1.
Results: 21 patients were recruited into the treatment group, and 10 patients into the control group. Mean serum levels of pro-ANP were significantly higher following T-LAAO compared to controls. For serum pro-BNP and sodium, there was no discernible divergence in temporal trends between the two groups. Mean arterial pressure decreased post-procedure in cases, but not in controls. 24-hours urine sodium and urine volume production was greater in cases compared to controls.
Conclusions: In contrast to surgical removal of the appendage, T-LAAO results in appendage stretch, with a resulting increase in ANP secretion, natriuresis and diuresis.
Poster Contributions Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Interventional Cardiology: Structural Heart Disease
Abstract Category: 24. Interventional Cardiology: Mitral and Structural Heart Disease
Presentation Number: 1241-140
- 2017 American College of Cardiology Foundation