Author + information
- Faith Kelly,
- James Watts,
- Terry Bauch,
- Joseph Murgo and
- Bernard Rubal
Background: Clinical concerns raising suspicion for cardiovascular disease in active duty military require definitive evaluations to diagnose limiting disease at an early stage. However, there remains limited information for assessing left and right heart hemodynamic response during supine exercise in young adults in high risk occupations. We report invasive cardiopulmonary exercise testing (iCPET) findings from 41 males and 1 female found free of heart disease.
Methods: This study is a retrospective review of catheterization records at Brooke Army Medical Center for active duty patients (ages: 19-40 years) in whom hemodynamic waveforms were obtained with multi-sensor high-fidelity catheters at rest and during supine exercise testing (53.1±12.6 watts), metabolic data were obtain for direct Fick cardiac outputs and angiography performed to exclude heart disease. Data are presented as mean ± standard deviation.
Results: Submaximal exercise was associated with approximately fourfold (P<0.001) increase in minute ventilation, O2 consumption and carbon dioxide production. Cardiac index, heart rate and stroke volume index increased (p<0.001) 3.2±1.4 L/min/M2, 40±15 bpm and 23±18 ml/min/M2, respectively. Pulmonary artery saturations fell from 77±3% to 55±7% (P<0.001), and the A-VO2 increase from 3.8± 0.5 to 8.3±1.5 (ml/dl). The oxygen-uptake efficiency slope for submaximal exercise was 1,557±423. No change was noted in mean right atrial pressure or pulmonary vascular resistance. A small increase (<1 mm Hg, P=0.043) was noted in right ventricular end-diastolic pressure, and mean pulmonary capillary wedge and left ventricular end-diastolic pressures increased ≈2±4 mmHg (P<0.001). Pulmonary artery systolic, diastolic and mean pressures increased (P<0.001) 9±4, 4±3 and 6±3 mm Hg, respectively. Left ventricular dP/dt increased from 1,505±316 to 2,727±682 mm Hg/sec (P<0.001) and systemic vascular resistance decreased (P<0.001) 37±12%.
Conclusions: This study furthers the understanding of the metabolic and hemodynamic changes in a young population during supine submaximal exercise.
Poster Contributions Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Timely Topics in Acute Coronary Syndromes
Abstract Category: 15. Interventional Cardiology: ACS/AMI/Hemodynamics and Pharmacology Presentation Number: 1242-157
- 2017 American College of Cardiology Foundation