Author + information
- Megha Prasad,
- Charanjit Rihal,
- Eric Matteson,
- Ryan Lennon,
- Lilach Lerman and
- Amir Lerman
Background: Serum uric acid is a marker of oxidative stress, and may predict cardiovascular events/outcomes. We aimed to determine whether elevated serum uric acid levels were predictive of worse outcomes in women undergoing percutaneous coronary intervention(PCI).
Methods: We retrospectively analyzed our Cardiovascular Catheterization Laboratory database, and included patients undergoing PCI from 1/2000 to 1/2007. Of 1,916 patients, 495 were women who underwent PCI. Patients were divided into normal uric acid (n=240) and high uric acid (n=255) groups. High uric acid was defined as >6.0 mg/dL. Patients were followed for adverse outcomes for a median of 47.1 (IQR 23.8, 62.8) months.
Results: Mean age was 66.6+12.7 years in the normal group vs. 70.5 + 11.2 years in the elevated uric acid group(p=0.01). Hypertension and diabetes were more prevalent in the elevated uric acid group (p<0.01). Multivariable analysis adjusting for potential confounders including age, hyperlipidemia, hypertension, BMI, diabetes, and chronic kidney disease, showed that elevated uric acid was associated with increased likelihood of death (HR 1.8, p=0.01) and the composite endpoint of death or subsequent myocardial infarction (HR 1.5, p=0.03).
Conclusions: In women, uric acid may be a biomarker of increased oxidative stress and a predictor of poor outcomes after percutaneous intervention. Further studies are necessary to understand the role of uric acid lowering therapy for risk modification in women.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Coronary Angiography, Intra-Vascular Imaging, Revascularization and Outcomes
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1166-337
- 2017 American College of Cardiology Foundation