Author + information
- Mathijs Bodde,
- Maaike Hermans,
- R. Wolterbeek,
- Arnoud van der Laarse,
- Martin Schalij and
- Johan Jukema
Background: It is hypothesized that high levels of low density lipoprotein-cholesterol (LDL-c) in patients with ST-segment elevation myocardial infarction (STEMI) could cause more reperfusion damage during primary percutaneous coronary intervention (pPCI) and therefore larger infarct size. The aim of this study was to evaluate the association of baseline LDL-c level with infarct size in patients with STEMI after pPCI.
Methods: All pts admitted between 2004-2014 with STEMI that underwent pPCI were included. Pts were excluded in case of out of hospital cardiac arrest, treatment delay ≥10 hours or no complete reperfusion after pPCI in the culprit vessel. Plasma peak CK level was used for infarct size and defined as the maximum measured value during admission.
Results: A total of 2248 pts were included in this study (mean age 61.8 ± 12.2 years; 25.0% female). The mean LDL-c level was 3.6 ± 1.1 mmol/L and median peak CK level was 1275 U/L (IQR 564-2590 U/L) in the entire study population. Multivariate analysis showed that baseline LDL-c level was independently associated with peak CK level. In addition, LAD as culprit vessel, initial TIMI 0-1 flow in the culprit vessel, male gender, treatment delay and prior aspirin therapy were also correlated with peak CK level (p≤0.05).
Conclusions: In pts with STEMI treated with pPCI, baseline LDL-c levels are independently associated with peak CK level. This conclusion is in line with the hypothesis that elevated LDL-c levels result in augmented reperfusion damage during pPCI.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Coronary Angiography, Intra-Vascular Imaging, Revascularization and Outcomes
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1166-340
- 2017 American College of Cardiology Foundation