Author + information
- Sophia Airharta,b,
- Yevgeniy Kharitona,b,
- William Lombardia,b,
- Kensey Goscha,b,
- James Sapontisa,b,
- James Granthama,b and
- James McCabea,b
Background: Trials examining the benefits of percutaneous revascularization (PCI) for ischemic cardiomyopathy have consistently excluded patients with chronic total occlusions (CTO). Whether patients with cardiomyopathy accrue similar quality of life benefits from CTO PCI as those with normal ejection fractions is unknown.
Methods: We examined baseline and 1 yr health status among patients undergoing successful CTO PCI in the OPEN CTO Registry. The primary outcomes were change in the Seattle Angina Questionnaire (SAQ) Summ Score and Rose Dyspnea Scale (RDS), stratified by left ventricular EF (Low, EF <30%; moderate, EF 30-49%; normal, EF ≥50%). Higher SAQ scores and lower RDS scores denote better health status. Differences in outcomes post-PCI were compared between EF groups using multivariable linear regression, adjusted for common confounders.
Results: Among 761 pts with successful CTO PCI, 8%, 25% and 66% had low, moderate or normal baseline EF, respectively. The overall population's health status improved significantly after treatment (+26.5±21 SAQ Summ and -1.0±1.4 RDS). As compared to those with an EF ≥50%, those with EF < 30% had significantly less improvement in SAQ summ scores (-5.23 [-9.05, -1.42]) and RDS scores (+0.44 [0.09, 0.78]) after multivariable adjustment (unadjusted scores showed similar trends, Figure1).
Conclusions: Patients with a severely reduced EF appear to derive less health status benefit, compared with those with normal systolic function after CTO revascularization.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Advances in Chronic Total Occlusion Intervention
Abstract Category: 20. Interventional Cardiology: Coronary Intervention: CTO
Presentation Number: 1282-129
- 2017 American College of Cardiology Foundation