Author + information
- Amjad M. Ahmed,
- Ihab Sulaiman,
- Mousa Alfaris,
- Dalia Ahmed,
- Ahmed Aljizeeri,
- Ahmed Alsaileek,
- Abdulbaset Sulaiman,
- Sherif Sakr and
- Mouaz Al-Mallah
Background: Coronary flow reserve (CFR) derived from cardiac positron emission tomography (PET) imaging has been shown to predict outcomes. However, it is unclear if CFR predictive value extends to patients with prior coronary artery bypass grafting (CABG). Our aim is to determine the prognostic value of CFR in patients with prior CABG.
Methods: We included 460 patients (mean age 65.2±10 yrs, males 79%) with prior CABG who underwent clinically indicated 82Rubidium PET. Patients were followed for major adverse cardiac events (MACE) including: cardiac death, myocardial infarction and unstable angina. CFR was estimated using one compartment model from dynamic reconstructions. Multivariate adjusted Cox proportional hazards regression models were used to determine the independent association of CFR and MACE after adjustments for confounders.
Results: In this cohort, there was high prevalence of cardiovascular risk factors: hypertension (93.5%), diabetes (72.4%) and dyslipidemia (89.8%). The median CFR of the included patients was 1.6. Over a median follow-up duration of 1.8 years (25th, 75th percentiles 1.0, 2.5), 55 (12%) patients experienced. Patients with CFR below the median (1.6) had increased risk of MACE (figure 1, p<0.001). In fully adjusted Cox proportional hazard models, patients with CFR>1.6 had lower MACE rate; (HR 95%CI was 0.52 (0.27-0.99); p=0.048)
Conclusions: Our results emphasize the ability of non-invasive CFR from cardiac PET to predict MACE in patients with prior CABG.
Moderated Poster Contributions
Non Invasive Imaging Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 10:15 a.m.-10:25 a.m.
Session Title: Noninvasive Assessment of Coronary Flow Reserve: Clinical Implications
Abstract Category: 30. Non Invasive Imaging: Nuclear
Presentation Number: 1136M-05
- 2017 American College of Cardiology Foundation