Author + information
- Amir Ali Ahmadia,b,
- Jonathan Leipsica,b,
- Kristian Oevrehusa,b,
- Sara Gaura,b,
- Angel Sanz Salvoa,b,
- Gina LaRoccaa,b,
- Pedro Morenoa,b,
- Farah Lajama,b,
- Bjarne Norgaarda,b and
- Jagat Narulaa,b
Background: The relationship between ischemia and coronary stenosis is far from perfect. There are many examples of ischemia without stenosis and stenosis without ischemia. We hypothesize that lesion specific low attenuation plaque (LAP) volume is an independent predictor of FFR and can differentiate FFR- and FFR+ lesions, independent of luminal stenosis.
Methods: In a prospective, multicenter study of 254 patients (64±10 years, 64% male), coronary CT angiography (CCTA), invasive angiography (ICA) and FFR were evaluated for 384 lesions. Ischemia was defined by invasive FFR ≤0.80. Various plaque's morphological characteristics quantified by semi-automated software (AutoPlaq) from standard CTA images. Multivariate analysis was performed to examine the relationship between various lesion characteristics and FFR.
Results: Total of 301 FFR- lesions and 83 FFR+ lesions were identified. Multivariate analyses revealed that amongst all lesions characteristics, only %luminal stenosis and LAP volume are independent predictors of FFR. Amongst the lesions categorized based on degree of stenosis (<50%, 50-70%, >70%), FFR- lesions had consistently smaller LAP volume compared to FFR+ lesions.
Conclusions: Degree of luminal stenosis and LAP volume are independent predictors of FFR. In lesions with similar degree of stenosis, FFR- lesions have significantly lower LAP volume compared to FFR+ lesions. The low LAP volume in FFR- lesions may explain the favourable outcomes amongst patients with FFR-lesions.
Relationship between FFR, Luminal Stenosis (QCA) and LAP volume in lesions with various degree of luminal stenosis
Moderated Poster Contributions
Non Invasive Imaging Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 11:15 a.m.-11:25 a.m.
Session Title: Noninvasive Assessment of Coronary Flow Reserve: Clinical Implications
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1136M-13
- 2017 American College of Cardiology Foundation