Author + information
- Seong-Mi Parka,b,
- Janet Weia,b,
- Louise Thomsona,b,
- Daniel Bermana,b,
- Eileen Handberga,b,
- John Petersena,b,
- Carl Pepinea,b and
- C. Noel Bairey Merza,b
Background: Women with signs and symptoms of ischemia but no obstructive coronary artery disease often have coronary microvascular dysfunction (CMD). However, mechanistic contributors of CMD remain poorly understood. We investigated relations between CMD, LV geometry and diastolic function in women with suspected CMD.
Methods: Of 337 Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction(WISE-CVD) study subjects, 195 patients who had both invasive coronary reactivity testing and cardiac MRI were included for this study. Patients were divided to 4 groups by coronary flow reserve (CFR) and myocardial perfusion reserve index (MPRI). The mass-cavity (M-C) ratio for LV concentric remodeling was obtained as LV mass/LV end diastolic volume. Diastolic function was assessed by peak filling rate (PFR).
Results: The age was 54 ± 11 years. M-C ratio was significantly different, although LV mass index was similar among groups. Group 4 showed the highest M-C ratio and smallest LV systolic and diastolic volumes (see Table). PFR was significantly different among 4 groups and was negatively related to M-C ratio (r= −0.408, p<0.001).
Conclusion: Among WISE-CVD women with suspected CMD, combined low CFR and MPRI is related to greater LV concentric remodeling, despite similar LV mass index. Moreover, greater concentric remodeling is related to more impaired LV diastolic function. These data suggest that CMD is related to LV concentric remodeling and may contribute to diastolic dysfunction in these subjects.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Coronary Angiography, Intra-Vascular Imaging, Revascularization and Outcomes
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1166-349
- 2017 American College of Cardiology Foundation