Author + information
- Rachelle Morgenstern,
- Randy Yeh,
- Adam Castano,
- Mathew Maurer and
- Sabahat Bokhari
Background: Non-invasive imaging to diagnose and track amyloid load are central for the care of patients with cardiac amyloidosis. Fluorine-18 sodium fluoride (NaF) is a widely available isotope and Positron Emission Tomography (PET) allows for absolute quantification of tracer uptake.
Methods: As part of a prospective pilot study, patients with biopsy-proven transthyretin (TTR) and light chain cardiac amyloidosis (AL) (5 TTR, 2 AL) and 5 controls, underwent PET imaging. Scans were assessed visually for qualitative tracer uptake. Using semi-automatic software, scans were analyzed for tracer uptake using standard uptake values in the entire myocardium (SUVm) and in a 17-segment cardiac model.
Results: Qualitative NaF uptake was absent in controls and only background activity was visualized in AL patients. There was qualitative NaF uptake in TTR patients. The medians (inter-quartile range) for SUVm of controls and AL patients were comparable at 0.8 (0.4-0.9) and 0.95 (0.9-1.0), respectively. A difference was noted for SUVm of TTR patients at 1.5 (1.4-1.7), almost two times higher relative to SUVm of controls and AL patients. Regional myocardial NaF uptake was heterogeneous in TTR patients.
Conclusions: NaF PET effectively imaged TTR patients, and distinguished them from AL patients and controls. Semi-automatic software allowed for quantification of radiotracer uptake and regional distribution. NaF may be useful for monitoring disease progression and localizing fibril deposition in TTR patients.
Moderated Poster Contributions
Non Invasive Imaging Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 10:00 a.m.-10:10 a.m.
Session Title: Emerging Applications for Imaging Cardiac Amyloidosis: Nuclear Cardiology
Abstract Category: 30. Non Invasive Imaging: Nuclear
Presentation Number: 1307M-05
- 2017 American College of Cardiology Foundation