Author + information
- Anna Liza Valina-Toth,
- Judith Boura,
- Gilbert Raff and
- Kavitha Chinnaiyan
Background: The association of vitamin D deficiency to coronary artery disease (CAD) on coronary CT angiography (CTA) is not well known.
Methods: A retrospective cross-sectional study was conducted in adult Caucasians and African Americans (AA) without known CAD enrolled in a CTA registry. Patients with 25-OH vitamin D levels obtained a year prior or after the CTA and who were not on vitamin D supplementations were included. Univariate analysis was performed across 3 vitamin D groups: deficiency <20 ng/ml, insufficiency 21-29 ng/ml and normal 30-150 ng/ml. Multivariate analysis adjusted for age, sex, body mass index, history of hypertension, hyperlipidemia, diabetes mellitus, smoking, race and season was performed to determine the association between vitamin D (continuous variable) and stenosis severity on CTA.
Results: Of the 2445 patients, there were 43% males, 10% AA; 28% were vitamin D deficient (<20 ng/ml). Multivariate analysis revealed no association between vitamin D and presence of CAD (stenosis >0). However, there was strong inverse correlation between vitamin D levels and >50% stenosis (Odd Ratio [OR] = 0.87, confidence interval [CI] = 0.78-0.97, p=0.01) and >70% stenosis (OR = 0.78, CI = 0.67 – 0.90, p = 0.001).
Conclusions: These data demonstrate that vitamin D deficiency is independently associated with coronary stenosis > 50% on CTA. Further studies are needed to determine the temporal and ethnic associations between vitamin D levels and CAD severity.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: Applications in Novel Disease States and Clinical Scenarios
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1117-201
- 2017 American College of Cardiology Foundation