Author + information
- Negin Nezarat,
- Dong Li,
- Matthew Budoff,
- Rine Nakanishi,
- Nasim Sheidaii,
- Sina Rahmani,
- Kazuhiro Osawa,
- Hong Qi,
- Michael Kim,
- Eranthi Jayawardena,
- Nicolai Hathiramani,
- Ferdinand Flores and
- George Karpouzas
Introduction: The presence of accelerated coronary artery disease in rheumatoid arthritis (RA) was previously reported. The goal of this study was to investigate if using high sensitivity cardiac troponin I (hs-cTnI) identifies patients at higher coronary atherosclerosis risk.
Method: A total of 146 asymptomatic RA patients (average age 53±11 years, women 87.6%) without history of ischemic heart disease who underwent coronary CT angiography were enrolled in the study. Serum high sensitivity cardiac troponin I (hs-cTnI) was quantified for each individual at the time of CT. The association between hs-cTnI and incident coronary artery plaque was assessed by a multivariate regression model; hs-cTnI> 1.5 pg/ml was defined as a threshold of high risk.
Results: Median cardiac troponin I was 1.0 pg/ml. In our sample 71% of patients had any coronary artery plaque. High levels of serum cardiac troponin (hs-cTnl >1.5 pg/ml) was associated with a significantly higher risk of coronary plaque presence (OR 5.3; 95%CI 1.5, 18.1; p=0.005 crude model); The risk remained significant after adjustments for age, gender, race, diabetes, family history CAD, high cholesterol, smoking and other traditional CAD risk factors (OR 7.4; 95%CI 1.7, 29.4; p=0.008). Notably the above results were more robust in over 50 years old patients.
Conclusions: We identified a significant association between increased cardiac troponin I levels and the presence of any coronary artery plaque in a cohort of RA patients. A thresholf of hs-cTnI > 1.5 pg/ml may facilitate cardiovascular risk stratification in patients with RA.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: Applications in Novel Disease States and Clinical Scenarios
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1117-203
- 2017 American College of Cardiology Foundation