Author + information
- Koutagiar Peter Iosifa,b,
- Konstantinos Toutouzasa,b,
- Georgios Benetosa,b,
- Nikoletta Piannoua,b,
- Alexios Antonopoulosa,b,
- Alexandros Georgakopoulosa,b,
- Ioannis Skoumasa,b,
- Spyridon Galanakosa,b,
- Angeliki Rigatoua,b,
- Pavlos Kafourisa,b,
- Andreas Synetosa,b,
- George Spyroua,b,
- Charalambos Antoniadesa,b,
- Eleftherios Tsiamisa,b,
- Constantinos Anagnostopoulosa,b,
- Dimitris Tousoulisa,b,
- First Department of Cardiologya,b and
- Medical Schoola,b
Background: Visceral adipose tissue (VAT) produces a wide range of proinflammatory molecules which may play a pivotal role in the regulation of signaling pathways of adjacent tissues such as the arterial wall. Alterations of lipid hepatic accumulation, partially caused by adipose tissue dysfunction, lead to a proatherothrombotic milieu in patients with familial dyslipidemias. In this study, we investigate the association between VAT biological activity, arterial inflammation and liver metabolism in patients with dyslipidemias, using 18F-Fluorodeoxyglycose Positron Emission Tomography (FDG-PET).
Methods: High sensitivity (hs)-CRP, fibrinogen and FDG PET imaging markers were measured in 28 patients with dyslipidemias free of statin therapy. Quantification of VATarea was performed from Hounsfield units (HU) maps for fat, which were applied on a single slice axial image at the level of L4-L5 intervertebral space. VAT TBR was also assessed and the VAT × TBR product (VATact), a novel marker of visceral fat biological activity was calculated. FDG uptake was quantified as target-to background ratio (TBRABD) in axial slices of the abdominal aorta. FDG uptake was also assessed in the liver by dividing SUVmax with the mean SUV of the superior vena cava (TBRLIVER).
Results: There was a positive correlation between VATact and TBRABD(R=0.47, p=0.005) as well as between VATarea and TBRABD (R=0.52, p=0.001). TBRABD was more strongly associated with TBRLIVER(R=0.78, p=0.005). Regarding the association of local inflammation with circulating biomarkers there was a positive correlation between TBRABD and both hs-CRP and fibrinogen values (R=0.54, p=0.006 and R=0.51, p=0.005). Furthermore, serum fibrinogen was weakly associated with VAT area (R=0.39, p=0.05). Finally, a positive correlation between TBRLIVER and both hs-CRP and fibrinogen values was observed (R=0.63, p=0.001 and R=0.53, p=0.004 respectively).
Conclusions: Abdominal aortic wall inflammation correlates with VAT mass and metabolism as well as with hepatic FDG uptake in patients with dyslipidemias. Association of imaging indices with circulating biomarkers may imply an interplay between systemic and local inflammation.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: Applications in Novel Disease States and Clinical Scenarios
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1117-204
- 2017 American College of Cardiology Foundation