Author + information
- Chirag Agarwala,b,
- Carlos Santos-Gallegoa,b,
- Juan Antonio Requena-Ibaneza,b,
- Allen Weissa,b,
- Rebecca Smollera,b,
- Valentin Fustera,b,
- Juan Badimona,b and
- Angel Sanz Salvoa,b
Background: Cardiac magnetic resonance (CMR) has excellent diagnostic accuracy in patients with suspected acute myocarditis. The role of T1 mapping in myocarditis assessment is evolving
Methods: We included consecutive patients with clinical suspicion of acute myocarditis referred to CMR between 2012 and 2016, and reviewed their clinical histories. We compared patients with confirmed diagnosis of acute myocarditis (n=50, age 39±14, 60% male), patients on which myocarditis was excluded (n=21, age 40±13, 55% male), and age- and gender-matched healthy controls (n=50). T1 mapping was performed from a Look-Locker sequence 10 minutes after contrast injection. Myocardial mechanics were quantified using CMR-strains (feature-tracking).
Results: Patients with confirmed acute myocarditis showed lower post-contrast T1 time than both patients with excluded myocarditis (306±41 vs 371±69 ms, p<0.01), as well as healthy controls (381±37 ms, p<0.01).
Compared with the highest T1 tertile, myocarditis patients in the lowest tertile showed more severe myocarditis: longer hospitalization, increased need for inotropic and diuretic drugs, higher cardiac enzyme levels, impaired left ventricular (LV) function, more LV dilatation, and higher LV filling pressures (Table).
Myocarditis patients in the lowest T1 tertile also demonstrated worse LV functional recovery at follow-up (Table).
Conclusions: T1 mapping using LL is an effective tool to evaluate the severity and prognosis of patients with acute myocarditis
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: MR Characterization and Function
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1118-211
- 2017 American College of Cardiology Foundation