Author + information
- Liselotte C.R. Hensen,
- Kathleen Goossens,
- Joris Rotmans,
- Johan Jukema,
- Victoria Delgado and
- Jeroen Bax
Background: Left ventricular (LV) global longitudinal strain (GLS) as a measure of LV systolic function has been associated with prognosis in the general population. The prognostic impact of LV GLS in patients with stage 4 and 5 chronic kidney disease (CKD) remains unexplored. We investigate the association between LV GLS and all-cause mortality in patients with stage 4 and 5 CKD.
Methods: Patients with stage 4 and 5 CKD were divided into 4 groups according to quartiles of LV GLS (%): first quartile (LV GLS<10.6%, worst function), second quartile (LV GLS 10.6-15.1%), third quartile (LV GLS 15.2-17.8%) and fourth quartile (LV GLS>17.8%, best function). The primary endpoint was all-cause mortality.
Results: Of 315 patients (62±14 years, 66% male), 65% had stage 4 CKD and 35% stage 5 CKD. During a mean follow-up of 39±31 months, 34% patients underwent renal transplantation and 34% died. Patients with LV GLS<10.6% showed significantly increased rates of all-cause mortality (Figure, log-rank p<0.001). LV GLS<10.6% was independently associated with increased risk for all-cause mortality (HR 2.30, 95% CI [1.21-4.37], p=0.011) after correcting for age, gender, albumin levels, atrial fibrillation and renal transplantation as time dependent covariate.
Conclusions: In patients with stage 4 and 5 CKD, severely impaired LV GLS is independently associated with worse prognosis, even after correcting for renal transplantation.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Novel Echocardiographic Methods for Assessing Cardiac Function
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1120-230
- 2017 American College of Cardiology Foundation