Author + information
- Cristina Di Stefano,
- Giulia Bruno,
- Gayatri Acharya,
- Rachel Le,
- Lynn Fussner,
- Patompong Ungprasert,
- Leslie Cooper,
- Lori Blauwet,
- Patricia Pellikka,
- Jay Ryu,
- Eva M. Carmona and
- Hector Villarraga
Background: Sarcoidosis is a systemic granulomatous disease that can affect the myocardium. Conventional 2D echocardiography identifies late complications, while strain analysis may detect early cardiac involvement.
Methods: We retrospectively evaluated 83 consecutive patients referred to our Institution from 2005 to 2016 with cardiac sarcoidosis (CS) established by biopsy, PET or cardiac MRI, and transthoracic echocardiograms. Left (LV) and right ventricular (RV) strain parameters were analyzed and compared to an age and gender matched control population.
Results: Mean age was 50.6±11.2 years, 35% were female. 30% of the patients had a positive endomyocardial biopsy, 29% and 15% typical MRI and PET findings (delayed enhancement and perfusion defects) and 27% met clinical and echocardiographic criteria based on the consensus statement from the Heart Rhythm Society. Table shows strain parameters in: cardiac biopsy proven sarcoidosis, sarcoid patients and age- and sex-matched healthy subjects with normal LV and RV systolic function. Patients with positive cardiac biopsy had reduced conventional and strain parameters compared to the other CS patients.
Conclusions: In sarcoid patients with normal LVEF, LV and especially RV strain is reduced; these findings were more pronounced in patients with a positive cardiac biopsy. This parameter is promising for the early detection of subclinical myocardial involvement when conventional parameters of ventricular function are normal.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Novel Echocardiographic Methods for Assessing Cardiac Function
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1120-232
- 2017 American College of Cardiology Foundation