Author + information
- Stephen Broughton,
- Wesley O'Neal,
- Mouaz Al-Mallah,
- David Bluemke,
- Susan Heckbert,
- Joao Lima and
- Elsayed Soliman
Background: We hypothesized that concomitant presence of normal findings on routine electrocardiogram (ECG) and cardiac magnetic resonance imaging (MRI) identifies a group at low risk to develop heart failure (HF) which could improve prediction of HF in the general population.
Methods: This analysis included 4,986 (mean age=62 ± 10 years; 52% women; 39% White; 13% Chinese-American; 26% Black; 22% Hispanic) participants with complete ECG and cardiac MRI data from the Multi-Ethnic Study of Atherosclerosis who were free of baseline HF. A normal ECG was defined as the absence of major ECG abnormalities as defined by Minnesota ECG Classification, and a normal MRI was defined as the absence of contractile dysfunction (EF<55%) or abnormal left ventricular mass (>95th percentile). Cox regression was used to compute the risk of developing HF events across different combinations of normal ECG and MRI.
Results: There were 3,988 (80%) participants with normal findings on both measures, 894 (18%) with either a normal ECG or normal MRI, and 104 (2%) with abnormal findings on both ECG and MRI. Over a median follow-up of 12.2 years, a total of 177 (3.6%) HF events were detected. Both normal ECG and MRI separately were associated with lower risk of HF and their combination was associated with much lower risk (Table).
Conclusions: Normal findings on noninvasive cardiac assessment identify individuals in whom the risk of HF is low. Further studies are needed to explore the utility of this low-risk profile in HF prevention strategies.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: MR Heart Failure and Pulmonary Hypertension
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1158-201
- 2017 American College of Cardiology Foundation