Author + information
- Mats Højbjerg Lassen,
- Sofie R. Biering-Sørensen,
- Flemming Javier Olsen,
- Rasmus Mogelvang,
- Jan Jensen and
- Tor Biering-Sorensen
Background: The ratio of early mitral inflow velocity (E) to global diastolic strain rate (e'sr) is a significant predictor in various patient populations; whether it works as a prognosticator of cardiovascular morbidity and mortality in a general population, is unknown.
Method: In a general population study, 1,238 participants underwent an echocardiography where global longitudinal strain (GLS) and E/e'sr were measured. The primary endpoint was the composite of incident heart failure (HF), acute myocardial infarction (AMI) or cardiovascular death (CVD).
Results: During follow-up (median 11 years), 140 (11.3%) participants were diagnosed with AMI, HF or CVD.
After multivariable adjustment for echocardiographic and clinical parameters, E/e'sr remained an independent predictor of the combined endpoints [HR 1.83 95% CI 1.11-3.03 p=0.018, per 1 m increase].
GLS modified the relationship between E/e'sr and outcome (figure). E/e'sr was a superior predictor in participants with preserved GLS (≥18%) as opposed to participants with impaired GLS (<18%)(figure). In participants with preserved GLS, E/e'sr predicted the composite outcome even better than E/e’ [HR 1.0 [0.9-1.1], p=0.66 for E/e'].
Conclusions: In the general population, E/e'sr provides independent and incremental prognostic information regarding cardiovascular morbidity and mortality. Furthermore, E/e'sr is more sensitive than E/e’ in participants with preserved GLS.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Applications of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1160-216
- 2017 American College of Cardiology Foundation