Author + information
- Daniel Modin,
- Morten Sengeløv,
- Peter Jørgensen,
- Niels Eske Bruun,
- Flemming Javier Olsen,
- Maria Dons,
- Thomas Fritz-Hansen,
- Jan Jensen and
- Tor Biering-Sorensen
Background: A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in atrial fibrillation (AF) has recently been proposed. Whether this method is superior in systolic heart failure (HFrEF) patients with AF remains unknown.
Methods: Echocardiograms from 151 patients with HFrEF and AF during examination were analysed offline. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments. To adjust for the varying heart cycle length in AF, correction of GLS was calculated by indexation with the square root of the RR-interval, (RR)^(1/2). End point was all-cause mortality.
Results: During a median follow-up of 2.7 years, 40 patients (26.5%) died. Neither uncorrected GLS (p=0.056) or LVEF (p=0.053) were significantly associated with all-cause mortality. After (RR)^(1/2) indexation, corrected GLS became a significant predictor of all-cause mortality (HR 1.16, 95CI 1.02-1.22, p=0.014, per %/sec^0.5 decrease) (Figure). Corrected GLS remained an independent predictor of mortality after multivariable adjustment (age, sex, mean heart rate, mean arterial pressure)(HR 1.10, 95CI 1.01-1.21, p=0.033 per %/ sec^0.5 decrease).
Conclusions: Decreasing GLS/(RR)^(1/2), but not uncorrected GLS or LVEF, was significantly associated with increased risk of all-cause mortality in HFrEF patients with AF and remained an independent predictor after multivariable adjustment.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Applications of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1160-217
- 2017 American College of Cardiology Foundation