Author + information
- Akanksha Agrawal,
- Andre Dias,
- Deepanshu Jain and
- Vincent Figueredo
Background: Stress echocardiography is the current standard for cardiac risk stratification of patients undergoing orthotopic liver transplantation (OLT). This study was aimed to evaluate the role of dobutamine stress echocardiography (DSE) in predicting major adverse cardiac events (MACE) in patients undergoing OLT.
Methods: This was a single center retrospective study including 144 patients who underwent OLT. MACE included myocardial infarction, stroke, heart failure, cardiovascular and all-cause death within 1 year of transplant.
Results: Study population was composed of 62% Caucasians, 23% African-Americans, 12% Hispanics and 3% Asians. The male to female ratio was 2.6:1 with mean age of 57. The most common cause of end stage liver disease (ESLD) was hepatitis C virus (HCV) (39%), followed by combined alcoholic and HCV ESLD (24%). Of the total 144 patients, 118 underwent DSE, of which 15 (13%) had a positive DSE and 103 (87%) had a negative result. The total incidence rate of MACE was 15%. In terms of predicting MACE, DSE had a sensitivity of 6%, specificity of 86%, PPV 7% and NPV 84%. The overall complication rate of DSE was 17%.
Conclusions: In this cohort, DSE had a low sensitivity for predicting MACE in first year post OLT. Additionally, its high complication rate raises a question as to its potential role as a test for cardiac risk stratification before OLT.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Applications of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1160-222
- 2017 American College of Cardiology Foundation