Author + information
- Attila Feher,
- Stendahl C. John,
- Nabil Boutagy,
- Eva Romito,
- Chi Liu and
- Albert J. Sinusas
Background: Stress CT myocardial perfusion imaging (MPI) is an important functional adjunct to CT angiography (CTA). Stressor induced changes in epicardial diameter could provide index of vascular reactivity, but are not routinely assessed during MPI.
Methods: Sequential CTA (120 kV, 350 mA) was performed in anesthetized closed chest canines (n=10) after contrast administration (iohexol, 350 mg/mL, average: 13 mL, 3 mL/s). Coronary diameters were measured at rest (REST-1), during adenosine infusion (ADE, 280μg/kg/min), at rest 30 min post ADE (REST-2), and during dobutamine infusion (DOB, 5μg/kg/min). Images were reconstructed at 70-80% of the cardiac cycle. Proximal luminal diameters were measured at preset distances from origins in 0.6 mm thick cross-sectional multi-planar reformatted (MPR) images perpendicular to vessel centerline.
Results: ADE decreased systolic blood pressure (SBP, −17±3 mmHg) and heart rate (HR, −4±2 beats/min), while DOB increased SBP (+79±9 mmHg), and HR (+24±4 beats/min). MPR was successful in 85% of CTA images. Epicardial coronary arteries dilated in response to ADE (Fig 1, LAD: 10±2%, LCx: 12±2%, RCA: 6±3%) and DOB (LAD: 8±4%, LCx: 17±2%, RCA: 11±4%). Rest diameter measurements were highly reproducible without significant change between studies (LAD: 1±2%, LCx: 2±2%, RCA: 1±2%).
Conclusions: CTA can provide reliable assessment of epicardial coronary diameter, ADE/DOB induced dilation, providing additional functional information about coronary vasoreactivity.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Expanding Clinical Applications
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1161-228
- 2017 American College of Cardiology Foundation