Author + information
- Kongkiat Chaikriangkrai,
- Ghanshyam Palamaner Subash Shantha,
- Aref Bin Abdulhak,
- Rudhir Tandon,
- Musab Alqasrawi,
- Hye Yeon Jhun and
- Gardar Sigurdsson
Background: The objective of this study is to investigate the diagnostic accuracy of coronary computed tomography angiography (CCTA) in patients referred for surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) using invasive coronary angiography (ICA) as gold standard.
Methods: We search databases for all diagnostic studies of CCTA in patients referred for SAVR or TAVR which reported diagnostic testing characteristics. Significant coronary artery disease (CAD) in both CCTA and ICA is defined by >50% stenosis in any coronary artery.
Results: Twelve studies evaluated 1446 patients (mean age = 78 years, 45% men, 76% TAVR) with the pooled prevalence of previous percutaneous coronary intervention and coronary artery bypass graft surgery of 32% and 18% respectively. The pooled prevalence of significant CAD determined by ICA is 43%. Hierarchical summary receiver operating characteristics shows a summary area under curve of 0.95. The pooled sensitivity, specificity, positive and negative likelihood ratios of CCTA in identifying significant CAD determined by ICA are 95%, 80%, 4.81 and 0.06 respectively. In subgroup analysis, the diagnostic profiles of CCTA are comparable between SAVR and TAVR.
Conclusions: CCTA has good diagnostic accuracy in patients with aortic valve stenosis, despite of high prevalence of coronary artery disease, and could reliable rule out significant coronary stenosis prior to valve surgery.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Expanding Clinical Applications
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1161-232
- 2017 American College of Cardiology Foundation