Author + information
- Jessica Buckley,
- Xenophon Papademetris,
- Carlos Mena-Hurtado,
- Peter A. Blume,
- Bauer Sumpio,
- Albert Sinusas and
- Mitchel Stacy
Background: Disruptions to the microcirculation may contribute to foot ulceration in patients with diabetes mellitus and critical limb ischemia (CLI). Single photon emission computed tomography (SPECT)/CT imaging assesses microvascular perfusion in the foot, but has not been evaluated in foot angiosomes or correlated to standard indices such as the ankle-brachial index (ABI), which assesses large vessel disease.
Methods: Diabetic CLI patients with non-healing ulcers (n=21) and healthy subjects (n=9) underwent resting SPECT/CT perfusion imaging of the feet (Fig. 1A). CT images were segmented into five angiosomes and used for quantifying radiotracer uptake (Fig. 1B), expressed as standardized uptake values (SUVs). SUVs were assessed in the angiosome containing the non-healing ulcer, while average SUVs for the whole foot were evaluated in healthy subjects. ABI was assessed in the limbs of CLI and healthy subjects.
Results: SPECT/CT imaging of angiosome perfusion correlated with ABI (r=0.51; P<0.01; Fig. 1C). SPECT/CT imaging of ulcerated foot angiosomes in CLI patients revealed significantly lower perfusion values when compared to average perfusion values in the feet of healthy subjects (P=0.04; Fig. 1D).
Conclusions: SPECT/CT imaging correlates with ABI and allows for comparison of angiosome perfusion between CLI patients and healthy subjects. Future application of SPECT/CT imaging may provide insight into local changes in microvascular perfusion after targeted therapeutic interventions.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Nuclear Cardiology: Beyond Perfusion
Abstract Category: 30. Non Invasive Imaging: Nuclear
Presentation Number: 1196-199
- 2017 American College of Cardiology Foundation