Author + information
- Koutagiar Peter Iosifa,b,
- Konstantinos Toutouzasa,b,
- Georgios Benetosa,b,
- Ioannis Skoumasa,b,
- Pavlos Kafourisa,b,
- Alexandros Georgakopoulosa,b,
- Spyridon Galanakosa,b,
- Nikoletta Pianoua,b,
- Mahmoud Abdelrasoula,b,
- Angeliki Rigatoua,b,
- George Spyroua,b,
- Constadina Aggelia,b,
- Eleftherios Tsiamisa,b,
- Dimitris Tousoulisa,b and
- Constantinos Anagnostopoulosa,b
Background: Ample evidence suggests that atherosclerosis constitutes an interplay between lipid accumulation and inflammatory activation. The aim of this study was the comparison of the degree of arterial inflammation as assessed by 18 F fluorodeoxyglucose Positron Emission Tomography (FDG-PET) measurements in asymptomatic individuals with different types of familial dyslipidemias.
Methods: Forty two individuals were enrolled. Specifically, 14 patients with familial combined hyperlipidemia (FCH), 14 with heterozygous familial hypercholesterolemia (heFH), both naïve of statin treatment and 14 normolipidemics matched for classical atherosclerotic risk factors underwent FDG-PET imaging. Radiotracer uptake within the arterial wall was quantified as target to background ratio (TBR) along the aorta. Blood lipid profile was obtained from dyslipidemics, high sensitive C-reactive protein (hs-CRP) and fibrinogen from all the subjects.
Results: TBR values were higher in FCH patients compared to heFH and controls (2.15±0.24 versus 1.93±0.20 versus 1.65±0.14, respectively, p<0.001). This difference remained significant even after adjustment for gender, age, hypertension and smoking (beta=0.23, p<0.001). TBR values were greater in FCH patients compared to heFH (p=0.02) and controls (p<0.001). Similarly, heFH patients exhibited higher TBR values compared to controls (p=0.01). FCH patients had significantly higher serum hs-CRP compared to heFH patients and controls (3.38±3.03 versus 2.12±2.85 versus 0.47±0.24 mg/dl, respectively, p=0.005). Similar were the results for serum fibrinogen levels (364±73.90 versus 301.42±74.24 versus 262.19±69.68 mg/dl, respectively, p=0.005). TBR values were associated with both hs-CRP and fibrinogen (R= 0.52, p= 0.01 and R= 0.64, p= <0.001).
Conclusions: Subclinical systemic inflammation as well as vascular inflammation, assessed by circulating and imaging indices, are increased in patients with FCH compared to heFH and non-dyslipidemics.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Nuclear Cardiology: Beyond Perfusion
Abstract Category: 30. Non Invasive Imaging: Nuclear
Presentation Number: 1196-200
- 2017 American College of Cardiology Foundation