Author + information
- Georgios Benetos,
- Konstantinos Toutouzas,
- Iosif Koutagiar,
- Alexandros Georgakopoulos,
- Nikoletta Pianou,
- Sofoklis Trachanellis,
- Nikolaos Patelis,
- George Agrogiannis,
- Nikolaos Bessias,
- Konstantinos Filis,
- Chris Clonaris,
- George Spyrou and
- Efstratios Patsouris
Background: 18F-fluorodeoxyglycose Positron Emission Tomography (FDG-PET) is regarded the gold standard for evaluation of vascular inflammation. Microwave radiometry (MWR) allows in vivo evaluation of arterial inflammation by measuring temperatures. We investigated whether a) there is a correlation between temperature measurements by MWR and FDG-PET uptake values in patients with high-grade carotid artery stenosis, and b) results from both methods correspond to histological findings.
Methods: Consecutive patients scheduled to undergo carotid endarterectomy were included. Carotid FDG uptake was quantified as target to background ratio (TBR) in consecutive axial slices starting at the bifurcation and extending 2 cm superiorly and 2 cm inferiorly. Temperature differences of atherosclerotic plaques were assessed by ΔT (maximum minus minimum measured temperature across the carotid) above the respective segments. In histology and immunohistochemistry extent of lipid core, severity of calcification and the intensity of CD68 (macrophage marker) were assessed semi-quantitatively.
Results: In total 21 patients were included in the study. There was a significant correlation between TBR and ΔT values of all carotids, which was higher for operated carotids only (R=0.40, p=0.01 and R=0.46, p=0.03, respectively). In table are summarized the histological and immunohistochemical results.
Conclusions: Carotid inflammation assessed by FDG uptake is associated with temperatures measured by MWR.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Nuclear Cardiology: Beyond Perfusion
Abstract Category: 30. Non Invasive Imaging: Nuclear
Presentation Number: 1196-206
- 2017 American College of Cardiology Foundation