Author + information
- Mayank Sardanaa,b,
- Steven Lubitza,b,
- Nisha Parikha,b,
- Connie Tsaoa,b,
- Emelia Benjamina,b,
- Nelson Schillera,b,
- Vasan Ramachandrana,b and
- David McManusa,b
Introduction: CHARGE-AF score is a strong predictor of incident atrial fibrillation (AF). Left atrial (LA) remodeling promotes the development of AF. We evaluated the effect of LA remodeling on the performance of CHARGE-AF score in predicting AF.
Methods: We measured maximum and minimum LA volumes (LAmax, LAmin, indexed to body surface area), along with LA emptying fraction (LAEF= (LAmax – LAmin)/LAmax) in 1720 participants of the Framingham Offspring Study (mean age 66±9 years, 55% women) without prevalent AF. CHARGE-AF score was calculated by a previously derived formula (Table 1). We calculated the Spearman's correlation coefficients for CHARGE-AF score and each LA index. Using Receiver Operating Characteristics (ROC) curves, we compared the performance of CHARGE-AF score for predicting incident AF at LAmax index of <34 (Group 1, normal LA size), 34-39 (Group 2, moderate LA enlargement), and ≥40ml/m2 (Group 3, severe LA enlargement).
Results: CHARGE-AF score had modest correlation with LA indices (Table 1). Over a median (interquartile range) follow up of 7.5 (1.4) years, 132 AF cases occurred. Performance of CHARGE-AF in group 3 was inferior its performance in groups 1 and 2 (Table 2).
Conclusions: CHARGE-AF score has a modest cross-sectional correlation with echocardiographic LA remodeling and its performance in predicting incident AF declines in the presence of severe LA enlargement. Incorporation of additional correlates of LA remodeling in the risk score might improve its performance.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Innovative Use of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1197-207
- 2017 American College of Cardiology Foundation