Author + information
- Daniel Pu,
- Anthony Holmes,
- Ningxin Wan,
- Lili Zhang and
- Cynthia Taub
Background: Strain echocardiography (echo) is increasingly recognized as an effective technique for predicting patient survival but its utility in mitral regurgitation (MR) is unclear. We sought to determine if the ability of strain measured by 2D speckle-tracking to predict all-cause mortality is different in patients with MR and ischemic heart disease (IHD) and nonischemic MR.
Methods: Transthoracic echo examinations were retrieved for patients with mild to severe MR from 2010-2012. After excluding patients with other valvular lesions, valve replacement, congenital heart disease, or incomplete echos, conventional and strain echocardiographic parameters were obtained in 112 (36 IHD, 76 nonischemic) patients.
Results: Over mean follow up of 33±22 months, 14 (39%) patients died in the ischemic group and 31 (41%) in the nonischemic group. There were no significant differences in age, sex, race, severe MR (37% vs. 38%), or LVEF (50±14% vs. 55±17%; P=0.19) between the groups. In a multivariate model including age, race, sex, HTN, HLD, DM, MR severity, LA size, LVESD and LVEF, significant predictors of all-cause-mortality in both groups were age and LVEF. When global longitudinal strain (GLS) was added to the model it was an independent predictor of mortality (HR=1.44, 95% CI: 1.01-2.06; P=0.04) in patients with MR and IHD but not in patients with nonischemic MR.
Conclusions: Left ventricular GLS is an independent predictor of all-cause mortality in patients with MR and IHD but not in nonischemic MR.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Innovative Use of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1197-218
- 2017 American College of Cardiology Foundation