Author + information
- Elie Dan Schouver,
- Pamela Moceri,
- Denis Doyen,
- Nathalie Tieulie,
- Viviane Queyrel,
- Delphine Baudouy,
- Pierre Cerboni,
- Sylvie Leroy and
- Emile Ferrari
Background: Cardiac sarcoidosis (CS) is associated with high morbidity and sudden death. The absence of specific symptoms and lack of diagnostic gold standard technique is challenging. New imaging methods could improve the diagnosis of CS. We investigated the prevalence of subclinical cardiac involvement by 2D speckle-tracking in a sarcoidosis population and evaluated its correlation with clinical outcomes.
Methods: We performed a prospective case-control longitudinal study including 35 patients with extra-cardiac sarcoïdosis according to the current guidelines and 35 healthy age- and gender-matched controls. All patients underwent a comprehensive echocardiographic study.
Results: Mean age of patients was 47.9±14.8 years old (22 women). Compared with controls, LV longitudinal strain was reduced in sarcoidosis patients: 3-chambers longitudinal strain (-17.1±3.4% vs −20.8±2.9%, p<0.001), 4-chambers longitudinal strain (-17.4±3.9 vs −20.8±1.8%, p<0.001), 2-chambers longitudinal strain (-17.2±3.4 vs −21.7±2.3%, p<0.001) and overall global LV longitudinal strain (LV GLS) (-17.2±3.1 vs −21.3±1.5%, p<0.0001). Circumferential LV strain was preserved in patients compared to controls (-19.9±-4.3% vs −21.3 ±1.5%, p=0.12). Impaired LV GLS was significantly associated with a composite secondary endpoint including all-cause mortality, heart failure, new arrhythmia occurrence, secondarily development of CS and cardiac device implantation (ICD or pacemaker). (HR 1.56; [1.16-2.11], p<0.01) on univariate analysis.
Conclusions: Cardiac imaging methods that improve the diagnosis of early forms of CS are currently lacking. LV longitudinal strain is impaired in sarcoidosis patients despite the absence of conventional evidence of cardiac involvement. This LV function parameter is also associated with the occurrence of new arrhythmia, secondarily developed CS and cardiac device implantation. Speckle-tracking imaging could be helpful in improving the diagnosis of cardiac localization in sarcoidosis patients and for risk stratification.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Innovative Use of Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1197-229
- 2017 American College of Cardiology Foundation