Author + information
- Rine Nakanishi,
- B ů ž ková Petra,
- Douglas Harrington,
- Kazuhiro Osawa,
- Yanting Luo,
- Indre Ceponiene,
- Sina Rahmani,
- Negin Nezarat,
- Hong Qi and
- Matthew Budoff
Background: Multiple protein biomarkers have been associated with coronary atherosclerosis, however, biomarkers failed to show a strong impact on the incremental prediction of cardiovascular events in prior studies. The aim of this study is to determine whether protein biomarkers predict coronary heart disease (CHD) events, independent and incrementally to traditional cardiovascular risk factors and compare coronary artery calcium (CAC) score at a mid-term and long-term follow-up, independent of traditional global risk factors (FRS).
Methods: From Multi-Ethnic Study of Atherosclerosis study, we identified 824 asymptomatic patients who had CAC score and protein biomarkers (Cutaneous T-cell attracting chemokine, Eotaxin, Fas Ligand, Hepatocyte growth factor, Interleukin-16, Monocyte Chemotactic Protein 3, and Serum soluble Fas). Area under the curves (AUC) by receiver operator characteristics were used to predict CHD events at mid-term (3 years) and longer-term (5 years) between clinical risk factors (age, race, gender, current smoking, total cholesterol, HDL-C, systolic blood pressure, and diabetes) alone and risk factors plus the biomarkers or CAC.
Results: Compared to risk factors alone, the biomarkers were more incrementally predictive of CHD events at the longer-term (C-statistics; 0.768 vs. 0.776, p=0.003) than mid-term (0.795 vs. 0.796, p=0.627). In contrast, CAC score predicted both longer-term (0.811, p<0.01) and mid-term events (0.822, p<0.01). The longer-term prediction of CHD events by CAC score was better than that by the biomarkers (p<0.01).
Conclusions: Multiple protein biomarkers can predict CHD events at long-term, but not mid-term follow-up, independent of risk factors. The prognostic value of CAC was better than that of biomarkers.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Non Invasive Imaging: Coronary Calcium Scoring and CV Risk Assessment
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1198-231
- 2017 American College of Cardiology Foundation