Author + information
- Indre Ceponienea,b,
- Rine Nakanishia,b,
- Kazuhiro Osawaa,b,
- Mitsuru Kanisawaa,b,
- Sina Rahmania,b,
- Negin Nezarata,b,
- Michael Kima,b,
- Eranthi Jayawardenaa,b,
- Alexander Broersena,b,
- Pieter Kitslaara,b and
- Matthew Budoffa,b
Background: Coronary artery calcium (CAC) progression is significantly associated with incident coronary heart disease and improves risk prediction. We aimed to determine which types of coronary plaque were associated with CAC progression.
Methods: Consecutive patients who were referred to our clinic for evaluation and had serial cardiac computed tomography scans performed were included in the study. Coronary artery plaque (total, fibrous, fibrous-fatty, low-attenuation, densely calcified) volume was quantified using QAngio CT Research Edition software package. Univariate and multivariate linear regression analyses were performed. To correct for differences in segment length, normalized plaque volume indexed to population segment length was calculated.
Results: 211 patients (mean ± standard deviation [SD] age 61.3±12.7 years, 75.4% males) were included in the analysis. Mean ± SD interval between baseline and follow-up scans was 3.3±1.7 years. At baseline, median CAC was 105 (25-75% interquartile range [IQR] 10-353). 14.2% of patients had a CAC of 0. Median annualized CAC progression was 32.73 (IQR 3.7-96.6). No CAC progression, CAC progression in 1-99, 100-399 and ≥400 Agatston score categories was observed in 17.5%, 31.3%, 28.9% and 22.3% of patients, respectively. In univariate analyses, annualized CAC was significantly associated with normalized total plaque (p<0.001), fibrous (p=0.001) and densely calcified plaque (p<0.001) progression. There was no association between CAC progression and low-attenuation plaque or fibrous-fatty plaque volume progression. In multivariate analyses, adjusted for age, gender, diabetes, hypertension, use of antihypertensive drugs, hyperlipidemia, lipid-lowering drugs, and current smoking, normalized total plaque (p<0.001), fibrous plaque (p=0.006) and densely calcified plaque volume (p<0.001) progression remained significantly associated with annualized CAC progression.
Conclusions: Progression of CAC was associated with increase in total plaque volume, fibrous plaque volume and densely calcified plaque volume. There was no association between CAC progression and low-attenuation or fibrous-fatty plaque progression.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Non Invasive Imaging: Coronary Calcium Scoring and CV Risk Assessment
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1198-233
- 2017 American College of Cardiology Foundation