Author + information
- Sawan Jalnapurkar,
- Parham Zarrini,
- Janet Wei,
- Behzad Sharif,
- Balaji Tamarappoo,
- Ahmed Al Badri,
- Galen Cook-Wiens,
- Daniel Berman,
- Louise Thomson and
- C. Noel Bairey Merz
Background: Cardiac magnetic resonance (CMR) imaging is used to study coronary microvascular dysfunction by measurement of myocardial perfusion reserve index (MPRI). Previous research has suggested a diff erence in MPRI measurement among women with coronary microvascular dysfunction with adenosine vs regadenoson. We prospectively compared CMR MPRI for adenosine vs regadenoson among healthy women.
Methods: 40 healthy women underwent stress/rest perfusion CMR at 1.5T, including 20 women with adenosine and 20 with regadenoson. Using CAAS MRV 3.3 software, MPRI was calculated as a ratio of the normalized upslope of myocardial opacification with contrast at stress vs rest and was analyzed with and without correction for rest and stress rate pressure product (RPP). T-tests and analysis of covariance using T-adjustment were performed.
Results: Subjects were of similar age in both groups (55 ± 10 vs 51 ± 10 yrs., p=0.17). There was no significant difference in mean BMI, ejection fraction, peak filling rate, resting heart rate (HR), resting blood pressure (BP), and peak stress (BP). Peak stress HR was lower in the adenosine vs. regadenoson group (95 ± 13 vs 108 ± 17 bpm, p=0.02). Transmural, subendocardial and subepicardial MPRI were similar. Even after correction for RPP, there was no significant difference between MPRI.
Conclusions: In healthy women, CMR MPRI is similar with adenosine and regadenoson. These results support the interchangeable use of either pharmacologic stressor for evaluating CMR perfusion.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: MR Scar and Perfusion
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1244-201
- 2017 American College of Cardiology Foundation