Author + information
- Eric Xie,
- Ricky Yu,
- Bharath Ambale Venkatesh,
- Hooman Bakhshi,
- Susan Heckbert,
- Elsayed Soliman,
- David Bluemke,
- Steven Kawut,
- Saman Nazarian and
- Joao Lima
Background: Strain imaging is a promising technique to quantify right atrial (RA) function. We investigated the association between incident atrial fibrillation (AF) and RA strain by feature tracking MRI.
Methods: This study was performed in a population free of prevalent CVD in MESA with AF identified from study ECGs, diagnosis codes, and Medicare claims. In this preliminary analysis, we included 4024 (of 5004) participants who underwent cardiac MRI at baseline. RA function was quantified by multi-modality tissue (feature) tracking (Toshiba Medical) from long-axis 4-chamber images. Adequate image quality was present in 3003 (75%) participants. Cox regression assessed the relationship of RA function (RA global longitudinal strain, RAGLS; free-wall strain, RAFWS; total emptying fraction, RATEF) and size (maximum volume index, RAVI) with incident AF after adjustment for traditional risk factors and left atrial volume index.
Results: Participants were aged 60±10 yrs, 45% male, 40% Caucasian, 29% African-American, 11% Chinese, 21% Hispanic, 40% hypertensive, 14% diabetic. Mean BMI was 28±5 kg/m2. Over 11 years of follow-up, 198 cases of incident AF were identified. Lower RAFWS and RAGLS were associated with higher risk of incident AF in fully adjusted models (HR per SD (20%) = 0.81, p = 0.017, HR per SD (26%) =0.81, p = 0.017, respectively). RAVI and RATEF did not predict AF events (Table).
Conclusions: RA strain predicts incident AF in a large multi-ethnic population free of AF and CVD at baseline.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: MR Scar and Perfusion
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1244-205
- 2017 American College of Cardiology Foundation