Author + information
- Runqing Huang,
- Matthew W. Urban,
- J. Kevin DeMarco,
- Waleed Brinjikji,
- John Huston III,
- Thanila A. Macedo,
- Eric J. Dailey,
- Mary E. Hagen and
- Sharon L. Mulvagh
Background: Microbubble contrast-enhanced ultrasound (CEUS) detects intraplaque neovascularization (IPN) associated with plaque vulnerability. Shear wave elastography (SWE) assesses mechanical stiffness of tissues by measuring shear wave speed (SWS): SWS is faster in stiffer tissues. We explored the relationship of lipoproteins and statin therapy to IPN and SWS.
Methods: Patients with known or suspected cardiovascular disease (CVD) were enrolled to undergo carotid imaging with CEUS [low mechanical index (< 0.20) imaging during Optison infusion] and SWE. IPN was graded by extent of microbubbles within the plaque. SWS (m/s) was measured by SWE. Statin treatment specifics [intensity (high, low-moderate); duration (≥ 5yrs, < 5 yrs)] were recorded.
Results: Of 169 patients, IPN was identified in 106 (63%). The presence of IPN was significantly associated with: increased carotid intima media thickness (CIMT), lower HDL, higher triglycerides, and statin therapy < 5 yrs. (Table 1). SWS was higher in those with statin therapy ≥ 5 yrs vs. < 5 yrs (4.57 ± 2.24 m/s vs. 3.64 ± 1.18m/s, p = 0.02). SWS was negatively correlated to total cholesterol and LDL (p=0.03, 0.04).
Conclusions: Carotid plaque vulnerability and stiffness, as measured by the new ultrasound techniques CEUS and SWE, were found to be associated with abnormalities in blood lipid profiles and duration of statin therapy. These observations introduce novel noninvasive methods for CVD risk stratification in patients with carotid plaque, beyond CIMT.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: New Technologies in Echocardiography
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1245-212
- 2017 American College of Cardiology Foundation