Author + information
- Anand Jeevarethinama,b,
- Shreenidhi Venurajua,b,
- Alain Dumoa,b,
- Sherezade Ruanoa,b,
- Miranda Rosenthala,b,
- Devaki Naira,b,
- Daniel Darkoa,b,
- Mark Cohena,b,
- Avijit Lahiria,b and
- Roby Rakhita,b
Objectives: The aim of the study was to evaluate the relationship between carotid disease by carotid ultrasound (US) and coronary artery disease(CAD) by computed tomography coronary angiography (CTCA) and to identify carotid parameters in predicting cardiovascular events in patients with asymptomatic type 2 diabetes (T2DM).
Research Design and Methods: A cohort of 259 asymptomatic T2DM patients were prospectively studied with carotid US to evaluate CIMT and carotid plaque and also underwent a CTCA.
Results: There were statistically significant differences between patients with and without carotid plaque for age (P <0.001), BMI (<0.001), systolic blood pressure (<0.001), eGFR (<0.03), CAC (<0.001), all Framingham risk score (P <0.001) and coronary plaque >50% (P 0.02) and 70% (P<0.001). Carotid plaque was present in 74% (59 of 95) of subjects with >50% stenosis (P<0.001) and 65% (28 of 43) of subjects with >70% stenosis.
Higher values of maximal IMT were associated with an increased risk of coronary plaque >50%, Odds ratio 1.21 (1.02, 1.44), P 0.03 and >70% coronary plaque, Odds ratio 1.23 (1.01, 1.50), P 0.04 after adjusting for traditional risk factors, and also the risk scores.
The occurrence of any event (total MACE) was estimated to be 7.1% in the group as a whole at the 34-month follow-up. The event occurrence was significantly higher in the group with carotid plaque (p 0.005).
Conclusions: Carotid plaque is a strong predictor of future cardiovascular events in asymptomatic diabetes with CAD.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Prognostic Implications of CT Angiography
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1247-235
- 2017 American College of Cardiology Foundation