Author + information
- Aristotelis Papayannis,
- Daniel Duprez,
- Yaorong Ge,
- James Terry,
- Edmond Kabagambe,
- Donald Lloyd-Jones,
- Joao Lima,
- Bharath Ambale-Venkatesh,
- Satoru Kishi,
- John Carr and
- David Jacobs
Background: Positive coronary artery (CA) remodeling is responsive to changes in coronary flow reserve and prominent early in plaque formation. We hypothesized that positive CA remodeling associates with left ventricular mass (LVM).
Methods: In 2,160 black and white male and female CARDIA participants aged 42-56 yr (average 50 yr) with non-contrast CT in 2010-2011, CA cross-sectional area was averaged across CA (CACSA_all). Echocardiographic LVM was assessed concurrently and 5 years later. In linear regression, LVM at average age 55 yr was predicted from CACSA_all within LV mass quartiles at average age 50 yr, adjusting for age, race, sex, clinic, and height, with or without adjusting for body mass index (BMI) and hypertension (HTN).
Results: CACSA_all (mean ± SD) was 21.2 ± 6.7 mm2. LVM change per CACSA_all increased compared to LVM value, more strongly the higher the starting LVM (p interaction = 0.02) (Table). Increases were partially attenuated but the interaction was more significant (p=0.0003) after further adjustment for BMI and HTN.
Conclusions: Positive remodeling of the CA as assessed by non-contrast cardiac CT is positively associated with increase in LVM over 5 years, especially when starting LVM was high, even after adjustment for BMI and HTN. The correlation between positive coronary remodeling and increase in LVM may indicate a common pathway of inflammation and growth factors that associates with CVD generally.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Prognostic Implications of CT Angiography
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1247-240
- 2017 American College of Cardiology Foundation