Author + information
- Kenji Fukushima,
- Yasuhiro Goto,
- Michinobu Nagao,
- Mitsuru Momose,
- Masami Yoneyama,
- Yamato Shimomiya,
- Naoki Serizawa,
- Eri Watanabe,
- Nobuhisa Hagiwara and
- Shuji Sakai
Background: This study was to evaluate the feasibility of detecting myocardial active inflammation in patients with cardiac sarcoidosis (CS) using cardiac diffusion weighted image (DWI).
Methods: 10 patients (age 61±10, male 6) who underwent both DWI and 18F-Fludeoxyglucose PET (FDG) were enrolled. After conventional cardiac 3T-MRI scan including LGE, low b value DWI with single-shot Turbo Spin Echo by peripheral pulse gating was performed. B factor was set as 0, 150, and 300. Visual analysis (invisible, equivocal, and visible) on each b value was done and patient with persistent visible myocardium at b=300 was defined as positive DWI. FDG was performed with low-carbohydrate diet protocol and 50 units/kg of heparin administration. FDG uptake of Whole heart was measured as whole myocardial SUVmax. Mid-level of short axis DWI images were divided into segments (anterior, septal, inferior, lateral wall) and were compared to segmental SUVmax in FDG.
Results: Four patients were under corticosteroid therapy out of total. DWI was positive in 4 patients. Whole myocardial SUVmax was significantly higher in DWI positive patients compared to those without (10±3.7 vs 3.9±2.5, p=0.001). In segmental analysis, visible segments at b=300 showed significant higher segmental SUVmax compared to invisible (9.7±3.9 vs. 2.2±2.7, p=0.012).
Conclusions: DWI has a potential to visualize active inflammation in CS and discriminate scarring myocardium in routine evaluation by cardiac MRI.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Non Invasive Imaging: MR Structure and Valuvular Heart Disease
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1290-215
- 2017 American College of Cardiology Foundation