Author + information
- Satoru Kishia,b,
- Jared Reisa,b,
- Bharath A. Venkatesha,b,
- Yoshiaki Ohyamaa,b,
- Donald Lloyd-Jonesa,b,
- Cora Lewisa,b,
- Stephen Sidneya,b,
- Pamela Schreinera,b,
- Kiang Liua,b,
- Samuel Giddinga,b,
- Akihiro Isogawaa,b and
- Joao Limaa,b
Background: Adverse left ventricular (LV) remodeling may increase myocardial stiffness and be associated with diastolic function alterations including strain rate.
Methods: CARDIA is a prospective study that enrolled Black and White adults from 4 US centers in 1985-86. We included participants with echocardiographic assessment at the Year-25 exam, excluding those with pregnant, gender change, valvular disease, or missing a covariate and an echo parameter to define the LV remodeling. We investigated how LV remodeling at middle age relates to diastolic myocardial deformation and traditional echocardiographic parameters. We categorized participants into four LV remodeling groups: normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy based on ASE guideline. We compared diastolic LV function [ratio of mitral early peak velocity/mitral annulus early peak velocity (E/e') ratio, left atrial volume/body surface area (LAV index), peak early diastolic strain rate in the 4-chamber longitudinal (Ell_SRe) and circumferential (Ecc_SRe) for diastolic indices] among the four LV remodeling groups using ANOVA.
Results: A total of 2,667 participants were included. Eccentric hypertrophy and concentric hypertrophy had higher LAV index and E/e’ ratio and worse Ell_SRe compared to normal geometry (Table). Eccentric hypertrophy had worse Ecc_SRe compared to normal geometry (Table).
Conclusions: Adverse LV remodeling is associated with worse measures of diastolic function.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Insights From Echocardiography Use
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1291-218
- 2017 American College of Cardiology Foundation