Author + information
- Christoffer Hagemann,
- Søren Hoffmann,
- Rikke Andersen,
- Thomas Hansen,
- Flemming Javier Olsen,
- Peter Jørgensen,
- Jan Jensen and
- Tor Biering-Sørensen
Background: Novel software allows for layer-specific evaluation of myocardial strain by speckle tracking echocardiography (2DSTE). However, the potential of layer-specific strain at rest for diagnosing coronary artery disease (CAD) in patients with suspected stable angina pectoris (SAP) remains unknown.
Methods: In total, 285 patients referred with suspected SAP, normal ejection fraction, and no previous cardiac history were prospectively enrolled. All patients were examined by echocardiography, including 2DSTE, exercise ECG, and coronary angiography (CAG). Layer-specific 2DSTE were performed in three apical views to provide longitudinal peak systolic strains. Stenoses ≥ 70% in ≥ 1 major coronary artery on CAG were considered as significant CAD.
Results: Of 285 patients, 104 had significant CAD (36%). Multivariable analysis including baseline data, conventional echocardiographic measurements, Duke score, and layer-specific strain measurements revealed midmyocardial (odds ratio, 1.16 [P=0.047]) and epicardial (odds ratio, 1.19 [P=0.048]) longitudinal strain (LS) as the only independent predictors of CAD. In direct comparison, midmyocardial and epicardial LS were significant superior to endocardial LS in diagnosing CAD (Figure).
Conclusions: In patients with suspected SAP, midmyocardial and epicardial LS from layer-specific 2DSTE at rest are independent predictors of CAD. In the present study midmyocardial and epicardial LS appear superior to endocardial LS for diagnosing CAD.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Insights From Echocardiography Use
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1291-224
- 2017 American College of Cardiology Foundation