Author + information
- Nobusada Funabashia,b,
- Hiroyuki Takaokaa,b,
- Koya Ozawaa,b,
- Masae Ueharaa,b,
- Koichi Sanoa,b and
- Yoshio Kobayashia,b
Background: Forward Projected Model-based Iterative Reconstruction SoluTion (FIRST) is a new reconstruction technique using CT providing successful reconstruction of high quality CT images, especially in low contrast imaging. To evaluate improvements in diagnostic accuracy of the detection of late enhancement (LE) of abnormal LE in left ventricular myocardium (LVM) using 2nd generation 320-slice CT with FIRST, we compared this with previous CT methods in non-ischemic cardiomyopathic patients.
Methods: This was a retrospective study of 88 patients (57 males; 57±16 years) who were suspected of having non-ischemic myocardial disease and underwent both late phase acquisition with cardiac CT and CMR to detect abnormal LE in LVM within 3 months. The first 52 consecutive patients (Group 1) underwent 16-slice CT (Light Speed Ultra 16) with 140 kV tube voltage and 330 mA tube current, and 1.5 T CMR. The next 18 patients (Group 2) underwent 1st generation 320-slice CT with 120 kV tube voltage, a 200-250 mA tube current, and 1.5T CMR and the remaining patients (Group 3) underwent 2nd generation 320-slice CT with FIRST, at 80 to 120 kV tube voltage, a 350-900 mA tube current, and 1.5T CMR or 3T CMR.
Results: Sensitivity, specificity, positive and negative predictive values (PPV and NPV), and overall accuracy of detection of LE on CT against those on CMR were 92, 88, 89, 92, and 90%, respectively for, in Group 1, and 90, 75, 82, 86, and 78%, respectively for, in Group 2, and 89, 100, 100, 90, and 94%, respectively, in Group 3. No significant differences were observed among the 3 groups. The LVM was divided into 17 segments, defined by the American Heart Association, and for segment-based analysis, sensitivity, specificity, PPV, NPV, and overall accuracy of detection of LE on CT against those on CMR were 67, 92, 68, 92, and 88%, respectively (Group 1), 69, 96, 83, 91, and 90% respectively (Group 2), and 63, 97, 79, 93, and 92%, respectively (Group 3). Specificity was significantly higher (P < 0.05) in Group 3 than in Group 1.
Conclusions: The diagnostic accuracy of the detection of LE on CT compared to CMR improved with the use of 2nd generation 320-slice CT with FIRST, especially regarding specificity.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Non Invasive Imaging: New Technologies
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1292-238
- 2017 American College of Cardiology Foundation