Author + information
- Balaji Tamarappoo,
- Yuka Otaki,
- Mhairi Doris,
- Yoav Arnson,
- Heidi Gransar,
- Sean Hayes,
- John Friedman,
- Louise Thomson,
- Frances Wang,
- Alan Rozanski,
- Piotr Slomka,
- Damini Dey and
- Daniel Berman
Background: Plaque analysis of coronary CT angiography (CTA) can provide comprehensive quantitative assessment of coronary plaque characteristics. Low density lipoprotein cholesterol (LDL) lowering is associated with plaque regression by IVUS. We tested the hypothesis that improvement in LDL is associated with beneficial changes in quantitative coronary plaque assessments by CTA.
Methods: 60 consecutive patients (47 men, 61 ±10 years) who underwent serial CTA were studied. Total, calcified, noncalcified and low-density noncalcified plaque volumes (TPV, CPV, NCPV and LDNCPV) were quantified with semiautomatic software (Autoplaque). Changes (Δ) in LDL and plaque volumes were defined as the difference between the second and baseline study. Patients were stratified by quartiles of ΔLDL: 1st quartile < −31mg/dl (n=15), 2nd quartile −31 to −3mg/dl(n=15), 3rd quartile −3 to 8mg/dl(n=14), and 4th quartile > 8mg/dl(n=16).
Results: Median LDL at baseline was 94mg/dl [interquartile range (IQR) 78 to 16 mg/dl] and median ΔLDL was −3mg/dl (IQR −31 to +8mg/dl). Beneficial changes in LDL were associated with a trend toward decreased progression of TPV (P=0.06) (Figure) and with a significant decrease in progression of NCPV (0.04). Beneficial changes in LDL were not associated with changes in LDNCPV or in CPV.
Conclusions: Beneficial change in LDL was associated with a decrease in non-calcified plaque volume on CTA as measured by automated quantitative software.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Non Invasive Imaging: New Technologies
Abstract Category: 27. Non Invasive Imaging: CT/Multimodality, Angiography, and Non-CT Angiography
Presentation Number: 1292-239
- 2017 American College of Cardiology Foundation