Author + information
- Christoph H. Saely,
- Philipp Rein,
- Andreas Leiherer,
- Alexander Vonbank,
- Daniela Zanolin and
- Heinz Drexel
Background: Remnant cholesterol recently has attracted interest as a marker of cardiovascular event risk and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). However, it is unknown whether remnant cholesterol also predicts the development of diabetes in patients who do not have diabetes yet.
Methods: We prospectively recorded incident diabetes over 6.1±3.7 years in 855 consecutive non-diabetic Caucasian patients with angiographically proven coronary artery disease (CAD). Diabetes was diagnosed according to ADA criteria.
Results: At baseline, 41.3% of our non-diabetic CAD patients had impaired fasting glucose (IFG); remnant cholesterol was significantly higher in IFG than in NFG patients (23±21 vs. 19±22 mg/dl; p<0.001). During follow-up, diabetes was newly diagnosed in 110 patients, i.e. in 12.9% of the study population. Remnant cholesterol strongly predicted diabetes both univariately (OR 1.88 [1.56-2.27]; p<0.001) and after multivariate adjustment including both fasting glucose and HbA1c values (OR 1.40 [1.40-2.11]; p<0.001).
Conclusions: We conclude that the incidence of diabetes is high in patients with established CAD and that remnant cholesterol strongly and independently predicts the development of diabetes in this population.
Moderated Poster Contributions
Prevention Moderated Poster Theater, Poster Hall, Hall C
Saturday, March 18, 2017, 12:45 p.m.-12:55 p.m.
Session Title: The Intersection of Diabetes and ASCVD
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1222M-05
- 2017 American College of Cardiology Foundation