Author + information
- Lane Benesa,b,
- James Terrya,b,
- John Carra,b,
- David Jacobsa,b,
- David Goffa,b,
- Joseph Yeboaha,b,
- Amy C. Almana,b,
- Jamal Ranaa,b,
- Cheeling Chana,b,
- Kiang Liua,b and
- Tamar Polonskya,b
Background: Cross-sectional studies have shown an association between traditional cardiovascular (CV) risk factors, coronary atherosclerosis and pericardial adipose tissue volume (PATv). Little is known about determinants of PATv progression.
Methods: PATv was assessed at Year 15 (2000-2001) and Year 25 (2010-2011) exams using computed tomography (CT) in the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based cohort of white and black adults ages 18-30 at baseline. Cardiac CT was performed using 64 channel multi-detector scanners. Slices 15 mm above and 30 mm below the superior extent of the left main coronary artery were selected. Adipose tissue was defined as –190 to –30 Hounsfield units. CV risk factors including blood pressure, lipid levels, diabetes, tobacco use and BMI were measured at Y15 and Y25. Linear regression was used to examine associations between changes in risk factors and changes in PATv.
Results: In 2,191 men and women an increase in triglycerides and BMI were significantly associated with an increase in PATv. Tobacco use and an increase in diastolic blood pressure were associated with an increase in PATv, while an increase in HDL was associated with a decrease in PATv in women only (Table).
Conclusions: Modifiable risk factors are associated with changes in PATv, with differences between men and women. Further study on associations between changes in PATv and future CV events is warranted.
Moderated Poster Contributions
Prevention Moderated Poster Theater, Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-3:55 p.m.
Session Title: Innovations in Risk Assessment: Novel Biomarkers and Risk Prediction Tools
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1261M-03
- 2017 American College of Cardiology Foundation